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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directedIn addition, the regulatory elements that control the FIX gene expression in these cassetteswere screened for liver-specific effectiveness.

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: The liver has a complex cellular composition and a remarkable regenerative capacity.The primary cell types in the liver are two parenchymal cell populations, hepatocytes and cholangiocytesIn recent years, with the rapid development of genetic sequencing technologies, research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensivelyof cells to be transplanted to achieve liver regeneration and repair.

Keywords： liver regeneration     hepatocytes     cholangiocytes     stem cells     organoids     regulatory mechanisms     transplantation    

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Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity Article

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Engineering 2022, Volume 19, Issue 12,   Pages 153-165 doi: 10.1016/j.eng.2021.09.014

Abstract:

Accurately assessing and tracking the progression of liver-specific injury remains a major challengevalidation approach built on the mutuality between serum and tissue biomarkers to characterize the liver-specificinflammation and repairing liver damage.and DPP-IV (as an extrahepatic marker of inflammation) for the accurate evaluation and tracking of liver-specificinjury–an application that allows for the differentiation of liver damage and inflammatory liver

Keywords： Carboxylesterase 1     Dipeptidyl peptidase 4     Liver injury     Validation tracking    

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract: Moreover, some stem cell-based products have been approved for marketing by different national regulatoryexist and need to be urgently addressed, especially in countries where establishment of appropriate regulatoryMore relevantly, the stem cell regulatory sciences need to be established or improved to more effectivelyevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatoryregulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory

Keywords： cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines     regulatory    

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Assessment of mobile and potential mobile trace elements extractability in calcareous soils using different

Mohsen Jalali, Ziba Hurseresht

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1186-4

Abstract: In NH4OAc, DTPA, and EDTA, the possibility of re-adsorption of trace elements is low.Understanding trace elements mobility in soils, extracting agents, and their relationships with soilcopper (Cu), nickel (Ni), and zinc (Zn) from calcareous soils utilizing various extracting agents to be specificThe speciation of extracted trace elements in solutions indicated that in the CaCl2, NaNO3, NH4NO3, andThe results of speciation of trace elements using NH4OAc, DTPA, and EDTA extracting agents showed that

Keywords： Mobility     Calcareous soils     Extracting agents     Trace elements    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1402-x

Abstract: Increasingly, 3re implementation is restricted by regulatory difficulties, particularly the invocation

Keywords： Blockchain     E-waste     Regulatory Policy     Copyright Laws     Repair-Reuse-Remanufacture     Toxicity    

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Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1,   Pages 3-15 doi: 10.1007/s11783-014-0734-1

Abstract: This critical review focuses on the issues associated with DBP regulatory compliance, including methodsPrecursor removal and alternative disinfectants are common practices for DBP regulatory compliance.

Keywords： Disinfection byproducts (DBPs)     drinking water standards     regulatory compliance     alternative disinfection    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Linking elements to outcomes of knowledge transfer in the project environment: Current review and future

Frontiers of Engineering Management 2022, Volume 9, Issue 2,   Pages 221-238 doi: 10.1007/s42524-022-0195-3

Abstract: A project is a specific effort to create a unique product, so it is a favorable place for knowledge creationHowever, the current research on the elements and outcomes of knowledge transfer (KT) in the projectThis study aims to conduct comprehensive research to determine and link the elements and outcomes ofFive-dimensional transfer elements and two-dimensional transfer outcomes were then identified and analyzedThis study builds a theoretical framework linking transfer elements to outcomes that can serve as a basis

Keywords： knowledge transfer     knowledge management     project management     project environment     literature review    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liverA total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverRLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality inpatients with HBV-related liver failure.

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 421-427 doi: 10.1007/s11684-012-0223-5

Abstract:

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsto get a regression formula for standard liver volume (SLV) and BSA.It turned out that the mean liver volume of the control group was 1 058±337 cm3.Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liverIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver

Keywords： liver volume variation     cirrhosis     acute liver failure (ALF)    

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Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract: Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specificIn contrast to conventional T cells (Tconvs), regulatory T cells (Tregs) play a major role in suppressing

Keywords： Chimeric antigen receptors     T cell     Treg     Alloimmunity     Bioengineering     Transplant     Autoimmunity    

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Title Author Date Type Operation

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Liver cell therapies: cellular sources and grafting strategies

Journal Article

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Assessment of mobile and potential mobile trace elements extractability in calcareous soils using different

Mohsen Jalali, Ziba Hurseresht

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Journal Article

Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Linking elements to outcomes of knowledge transfer in the project environment: Current review and future

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Journal Article

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Journal Article